Pargyline hydrochloride
Cat. No.：YN380153
| 产品名称: | Pargyline hydrochloride |
| CAS No.: | 306-07-0 |
| Chemical Name: | N-methyl-N-2-propyn-1-yl-benzenemethanamine, monohydrochloride |
| Synonyms: | Pargylamine hydrochloride |
| 分子量: | 195.69 |
| 分子式: | C₁₁H₁₄ClN |
| SMILES: | C#CCN(C)CC1=CC=CC=C1.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pargyline hydrochloride 是一种不可逆的单胺氧化酶 (MAO) 抑制剂，对MAO-A和MAO-B的Ki分别为 13 μM 和 0.5 μM。Pargyline hydrochloride 具有降压和抗癌活性。 |
| IC50和靶点: | [{name:"MAO-B:0.5 μM (Ki)"},{name: "MAO-A:13 μM (Ki)"}] |
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Fuentes, J.A., Ordaz, A., and Neff, N.H.Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive ratsEur. J. Pharmacol.57(1),21-27(1979)
Yamori, Y., De Jong, W., Yamabe, H., et al.Effects of L-dopa and inhibitors of decarboxylase and monoamine oxidase on brain noradrenaline leves and blood pressure in spontaneously hypertensive ratsJ. Pharm. Pharmacol.24(9),690-695(1972)
Bianchi, P., Pimentel, D.R., Murphy, M.P., et al.A new hypertrophic mechanism of serotonin in cardiac myocytes: Receptor-independent ROS generationFASEB J.19(6),641-643(2005)
Puig, M., Wakade, A.R., and Kirpekar, S.M.Effect of the sympathetic nervous system of chronic treatment with parglyline and l-DOPAJ. Pharmacol. Exp. Ther.182(1),130-134(1972)
