Radafaxine hydrochloride
Cat. No.：YN360641
| 产品名称: | Radafaxine hydrochloride |
| CAS No.: | 106083-71-0 |
| Chemical Name: | (2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol, monohydrochloride |
| Synonyms: | GW-353162A; BW-306U |
| 分子量: | 292.20 |
| 分子式: | C₁₃H₁₉Cl₂NO₂ |
| SMILES: | O[C@]1(C2=CC=CC(Cl)=C2)[C@H](C)NC(C)(C)CO1.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Radafaxine hydrochloride (GW-353162A) 是 bupropion 的代谢活化物，DAT/NET 转运体抑制剂，能选择性的抑制去甲肾上腺素的再吸收。 |
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Lukas, R.J., Muresan, A.Z., Damaj, M.I., et al.Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: Aids to smoking cessationJ. Med. Chem.53(12),4731-4748(2010)
Bondarev, M.L., Bondareva, T.S., Young, R., et al.Behavioral and biochemical investigations of bupropion metabolitesEur. J. Pharmacol.474(1),85-93(2003)
Coles, R., and Kharasch, E.D.Stereoselective metabolism of bupropion by cytochrome P4502B6 (CYP2B6) and human liver microsomesPharm. Res.25(6),1405-1411(2008)
