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> 产品中心 > 抑制剂 & 激动剂 > Membrane Transporter/Ion Chann > Monoamine Transporter

Nisoxetine hydrochloride

Cat. No.:YN360884

  • CAS No. :57754-86-6

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    • 参考文献
    • 产品名称: Nisoxetine hydrochloride
      CAS No.: 57754-86-6
      Chemical Name: γ-(2-methoxyphenoxy)-N-methyl-benzenepropanamine, monohydrochloride
      Synonyms:
      分子量:307.82
      分子式:C₁₇H₂₂ClNO₂
      SMILES:CNCCC(OC1=CC=CC=C1OC)C2=CC=CC=C2.[H]Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Nisoxetine hydrochloride 是一种有效的和选择性的去甲肾上腺素转运蛋白(NET)的抑制剂,Kd值为 0.76 nM。Nisoxetine hydrochloride 是一种抗抑郁药和局部麻药,它可以阻断电压门控性钠通道。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Torres, G.E., Gainetdinov, R.R., and Caron, M.G.Plasma membrane monoamine transporters: Structure, regulation and functionNat. Rev. Neurosci.4(1),13-25(2003)

      Tyler, T.D., and Tessel, R.E.Amphetamine's locomotor-stimulant and noreprinephrine-releasing effects: Evidence for selective antagonism by nisoxetinePsychopharmacology (Berl)64(3),291-296(1979)

      Tyler, T.D., and Tessel, R.E.Norepinephrine uptake inhibitors as biochemically and behaviorally selective antagonists of the locomotor stimulation induced by indirectly acting sympathomimetic aminetic amines in micePsychopharmacology (Berl)69(1),27-34(1980)

      Foutz, A.S., Delashaw, J.B., Jr., Guilleminault, C., et al.Monoaminergic mechanisms and experimental cataplexyAnn. Neurol.10(4),369-376(1981)

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