BAY 41-8543
Cat. No.：YN322435
CAS No. ：256498-66-5
| 产品名称: | BAY 41-8543 |
| CAS No.: | 256498-66-5 |
| Chemical Name: | 2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine |
| Synonyms: | BAY 418543 |
| 分子量: | 420.4 |
| 分子式: | C21H21FN8O |
| SMILES: | FC(C=CC=C1)=C1CN2N=C(C3=NC(N)=C(N4CCOCC4)C(N)=N3)C5=C2N=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BAY 41-8543 是口服有效的，不依赖一氧化氮 (NO) 的可溶性鸟苷酸环化酶 (sGC) 的刺激物。BAY 41-8543 在大鼠的肺和全身血管床中具有血管舒张活性。BAY 41-8543 具有抗血小板作用，并有用于心血管疾病研究的潜力。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Stasch, J.P., Alonso-Alija, C., Apeler, H., et al.Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: In vitro studiesBr. J. Pharmacol.135,333-343(2002)
Stasch, J.P., Dembowsky, K., Perzborn, E., et al.Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studiesBr. J. Pharmacol.135,344-355(2002)
Evgenov, O.V., Kohane, D.S., Bloch, K.D., et al.Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilationAm. J. Respir. Crit. Care Med.176,1138-1145(2007)
