AZD3965
Cat. No.：YN360372
CAS No. ：1448671-31-5
| 产品名称: | AZD3965 |
| CAS No.: | 1448671-31-5 |
| Chemical Name: | 5-[[(4S)-4-hydroxy-4-methyl-2-isoxazolidinyl]carbonyl]-3-methyl-1-(1-methylethyl)-6-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione |
| Synonyms: | AZD 3965,AZD-3965 |
| 分子量: | 515.51 |
| 分子式: | C₂₁H₂₄F₃N₅O₅S |
| SMILES: | O=C1N(C(C)C)C2=C(C(C(N3OC[C@@](C)(O)C3)=O)=C(CC4=C(C)NN=C4C(F)(F)F)S2)C(N1C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD3965是选择性的MCT1抑制剂，Ki值为1.6 nM，比MCT2的选择性高6倍。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Polanski, R., Hodgkinson, C.L., Fusi, A., et al.Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancerClin. Cancer Res.20(4),(2014)
Bola, B.M., Chadwick, A.L., Michopoulos, F., et al.Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transportMol. Cancer. Ther.13(12),2805-2816(2014)
