AR-C155858
Cat. No.：YN360413
CAS No. ：496791-37-8
| 产品名称: | AR-C155858 |
| CAS No.: | 496791-37-8 |
| Chemical Name: | 6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-5-[[(4S)-4-hydroxy-2-isoxazolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione |
| Synonyms: | AR C155858 |
| 分子量: | 461.53 |
| 分子式: | C₂₁H₂₇N₅O₅S |
| SMILES: | O=C(C1=C2SC(CC3=C(NN=C3C)C)=C1C(N4C[C@@H](CO4)O)=O)N(C(N2CC(C)C)=O)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AR-C155858是选择性的单羧酸转运蛋白MCT1和MCT2抑制剂，Ki分别为2.3 nM和10 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ovens, M.J., Davies, A.J., Wilson, M.C., et al.AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10Biochem. J.425(3),523-530(2010)
Guan, X., Bryniarski, M.A., and Morris, M.E.In vitro and in vivo efficacy of the monocarboxylate transporter 1 inhibitor AR-C155858 in the murine 4T1 breast cancer tumor modelAAPS J.21(1),3(2018)
