7ACC2
Cat. No.：YN360900
CAS No. ：1472624-85-3
| 产品名称: | 7ACC2 |
| CAS No.: | 1472624-85-3 |
| Chemical Name: | 7-[methyl(phenylmethyl)amino]-2-oxo-2H-1-benzopyran-3-carboxylic acid |
| Synonyms: | |
| 分子量: | 309.32 |
| 分子式: | C₁₈H₁₅NO₄ |
| SMILES: | CN(C1=CC=C(C=C(C(O)=O)C(O2)=O)C2=C1)CC3=CC=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 7ACC2是MCT高效抑制剂，对[14C]-乳酸流入抑制的IC50值为11nM，是针对癌细胞乳酸转运的新型抗肿瘤分子。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Draoui, N., Schicke, O., Fernandes, A., et al.Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cellsBioorg. Med. Chem.21(22),7107-7117(2013)
Corbet, C., Bastien, E., Draoui, N., et al.Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effectsNat. Commun.9(1),1208(2018)
