10074-G5
Cat. No.：YN270023
CAS No. ：413611-93-5
| 产品名称: | 10074-G5 |
| CAS No.: | 413611-93-5 |
| Chemical Name: | N-[1,1'-biphenyl]-2-yl-7-nitro-2,1,3-benzoxadiazol-4-amine |
| Synonyms: | 10074-G5;10074G5;4-nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-7-amine;Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-yl)amine;N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-amine;N-[1,1′-Biphenyl-2-yl]-7-nitro-2,1,3-Benzoxadiazol-4-amine |
| 分子量: | 332.31 |
| 分子式: | C₁₈H₁₂N₄O₃ |
| SMILES: | O=[N+]([O-])C1=CC=C(NC2=CC=CC=C2C3=CC=CC=C3)C4=NON=C41 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 10074-G5是c-Myc-Max二聚化抑制剂，IC50值为146 μM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Follis, A.V., Hammoudeh, D.I., Wang, J., et al.Structural rationale for the coupled binding and unfolding of the c-Myc oncoprotein by small moleculesChem. Biol.15(11),1149-1155(2008)
Hammoudeh, D.I., Follis, A.V., Prochownik, E.V., et al.Multiple independent binding sites for small-molecule inhibitors on the oncoprotein c-MycJ. Am. Chem. Soc.131(21),7391-7401(2009)
Yap, J.L., Wang, H., Hu, A., et al.Pharmacophore identification of c-Myc inhibitor 10074-G5Bioorg. Med. Chem. Lett.23(1),370-374(2013)
Clausen, D.M., Guo, J., Parise, R.A., et al.In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerizationJ. Pharmacol. Exp. Ther.335(3),715-727(2010)
Müller, I., Larsson, K., Frenzel, A., et al.Targeting of the MYCN protein with small molecule c-MYC inhibitorsPLoS One9(5),(2014)
