10058-F4
Cat. No.：YN270195
| 产品名称: | 10058-F4 |
| CAS No.: | 403811-55-2 |
| Chemical Name: | 5-[(4-ethylphenyl)methylene]-2-thioxo-4-thiazolidinone |
| Synonyms: | c-Myc Inhibitor |
| 分子量: | 249.35 |
| 分子式: | C₁₂H₁₁NOS₂ |
| SMILES: | O=C1NC(S/C1=C/C2=CC=C(CC)C=C2)=S |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 10058-F4是c-Myc抑制剂，其阻止c-Myc-Max二聚化和c-Myc靶基因表达的反式激活。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Yin, X., Giap, C., Lazo, J.S., et al.Low molecular weight inhibitors of Myc-Max interaction and functionOncogene22(40),6151-6159(2003)
Huang, M.J., Cheng, Y.C., Liu, C.R., et al.A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemiaExp. Hematol.34(11),1480-1489(2006)
Guo, J., Parise, R.A., Joseph, E., et al.Efficacy, pharmacokinetics, tissue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in miceCancer Chemother. Pharmacol.63(4),615-625(2009)
Zirath, H., Frenzel, A., Oliynyk, G., et al.MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cellsProc. Natl. Acad. Sci. USA110(25),10258-10263(2013)
Zhang, P., Metukuri, M.R., Bindom, S.M., et al.c-Myc is required for the ChREBP-dependent activation of glucose-responsive genesMol. Endocrinol.24(6),1274-1286(2010)
