ML-9
Cat. No.：YN300006
CAS No. ：105637-50-1
| 产品名称: | ML-9 |
| CAS No.: | 105637-50-1 |
| Chemical Name: | 1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-1H-1,4-diazepine, monohydrochloride |
| Synonyms: | ML-9 hydrochloride |
| 分子量: | 361.29 |
| 分子式: | C₁₅H₁₈Cl₂N₂O₂S |
| SMILES: | O=S(N1CCNCCC1)(C2=C3C=CC=C(Cl)C3=CC=C2)=O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ML-9 是 Akt 激酶的选择性强效抑制剂，可抑制肌球蛋白轻链激酶 (MLCK) 和基质相互作用分子1 (STIM1) 的活性。 ML-9 抑制 MLCK，PKA 和 PKC 活性，Ki值分别为 4、32 和 54 μM。 ML-9 通过刺激自噬小体的形成并抑制其降解来诱导自噬 (autophagy)。 |
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Ito, S., Kume, H., Honjo, H., et al.ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealisEur. J. Pharmacol.486,325-333(2004)
Smith, U., Carvalho, E., Mosialou, E., et al.PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytesBiochem. Biophys. Res. Commun.268,315-320(2000)
