Mavacamten
Cat. No.：YN300014
CAS No. ：1642288-47-8
| 产品名称: | Mavacamten |
| CAS No.: | 1642288-47-8 |
| Chemical Name: | 3-(1-methylethyl)-6-[[(1S)-1-phenylethyl]amino]-2,4(1H,3H)-pyrimidinedione |
| Synonyms: | MYK461; SAR439152 |
| 分子量: | 273.33 |
| 分子式: | C₁₅H₁₉N₃O₂ |
| SMILES: | CC(N(C1=O)C(C=C(N[C@H](C2=CC=CC=C2)C)N1)=O)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Mavacamten (MYK461) 是具有口服活性的心肌肌球蛋白的调节剂，其在牛心脏和人心脏中的IC50值分别为 490，711 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Green, E.M., Wakimoto, H., Anderson, R.L., et al.A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in miceScience351(6273),617-623(2016)
Stern, J.A., Markova, S., Ueda, Y., et al.A small molecule inhibitor of sarcomere contractility acutely relieves left ventricular outflow tract obstruction in feline hypertrophic cardiomyopathyPLoS One11(12),e0168407(2016)
