para-Nitroblebbistatin
Cat. No.：YN300023
| 产品名称: | para-Nitroblebbistatin |
| CAS No.: | 1621326-32-6 |
| Chemical Name: | (3aS)-1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-(4-nitrophenyl)-4H-pyrrolo[2,3-b]quinolin-4-one |
| Synonyms: | p-Nitroblebbistatin |
| 分子量: | 337.33 |
| 分子式: | C₁₈H₁₅N₃O₄ |
| SMILES: | O=C1[C@]2(C(N(CC2)C3=CC=C(C=C3)[N+]([O-])=O)=NC4=C1C=C(C=C4)C)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | para-Nitroblebbistatin 是一种无细胞毒性、光稳定、无荧光、特异性的肌球蛋白 II (Myosin II) 抑制剂，可用于研究肌球蛋白 II 在生理学、发育和细胞生物学中的特殊作用。 |
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Straight, A.F., Cheung, A., Limouze, J., et al.Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitorScience299(5613),1743-1747(2003)
Kovács, M., Tóth, J., Hetényi, C., et al.Mechanism of blebbistatin inhibition of myosin IIJ. Biol. Chem.279(34),35557-35563(2004)
Limouze, J., Straight, A.F., Mitchison, T., et al.Specificity of blebbistatin, an inhibitor of myosin IIJ. Muscle Res. Cell Motil.25(4-5),337-341(2004)
Kolega, J.Phototoxicity and photoinactivation of blebbistatin in UV and visible lightBiochem. Biophys. Res. Commun.320(3),1020-1025(2004)
Sakamoto, T., Limouze, J., Combs, C.A., et al.Blebbistatin, a myosin II inhibitor, is photoinactivated by blue lightBiochemistry44(2),584-588(2005)
Képiró, M., Várkuti, B.H., Végner, L., et al.para-Nitroblebbistatin, the non-cytotoxic and photostable myosin II inhibitorAngew. Chem. Int. Ed. Engl.53(31),8211-8215(2014)
Verhasselt, S., Roman, B.I., Bracke, M.E., et al.Improved synthesis and comparative analysis of the tool properties of new and existing D-ring modified (S)-blebbistatin analogsEur. J. Med. Chem.136,85-103(2017)
