Blebbistatin
Cat. No.：YN300031
CAS No. ：674289-55-5
| 产品名称: | Blebbistatin |
| CAS No.: | 674289-55-5 |
| Chemical Name: | 1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one |
| Synonyms: | (±)-Blebbistatin |
| 分子量: | 292.33 |
| 分子式: | C₁₈H₁₆N₂O₂ |
| SMILES: | O=C1C2(O)C(N(C3=CC=CC=C3)CC2)=NC4=C1C=C(C)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Blebbistatin 是一种选择性的非肌肉肌球蛋白 II (NMII) 抑制剂，可促进角膜内皮细胞的定向迁移并加速伤口愈合，并更好地保留细胞连接完整性和屏障功能。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Straight, A.F., Cheung, A., Limouze, J., et al.Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitorScience299(5613),1743-1747(2003)
Kovács, M., Tóth, J., Hetényi, C., et al.Mechanism of blebbistatin inhibition of myosin IIJ. Biol. Chem.279(34),35557-35563(2004)
Limouze, J., Straight, A.F., Mitchison, T., et al.Specificity of blebbistatin, an inhibitor of myosin IIJ. Muscle Res. Cell Motil.25(4-5),337-341(2004)
Kolega, J.Phototoxicity and photoinactivation of blebbistatin in UV and visible lightBiochem. Biophys. Res. Commun.320(3),1020-1025(2004)
Sakamoto, T., Limouze, J., Combs, C.A., et al.Blebbistatin, a myosin II inhibitor, is photoinactivated by blue lightBiochemistry44(2),584-588(2005)
Lucas-Lopez, C., Patterson, S., Blum, T., et al.Absolute stereochemical assignment and fluorescence tuning of the small molecule tool, (-)-blebbistatinEuropean J. Org. Chem.2005(9),1736-1740(2005)
