SC75741
Cat. No.：YN410008
CAS No. ：913822-46-5
| 产品名称: | SC75741 |
| CAS No.: | 913822-46-5 |
| Chemical Name: | N-(6-benzoyl-1H-benzimidazol-2-yl)-2-(1-thieno[3,2-d]pyrimidin-4-yl-4-piperidinyl)-4-thiazolecarboxamide |
| Synonyms: | |
| 分子量: | 565.67 |
| 分子式: | C₂₉H₂₃N₇O₂S₂ |
| SMILES: | O=C(NC1=NC(C=CC(C(C2=CC=CC=C2)=O)=C3)=C3N1)C4=CSC(C(CC5)CCN5C6=NC=NC7=C6SC=C7)=N4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SC75741 是一种广泛，有效的NF-κB抑制剂，对p65的IC50为 200 nM。SC75741 可阻断influenza viruses复制。SC75741 通过损害NF-κB亚基 p65 的 DNA 结合，导致细胞因子，趋化因子和促凋亡因子的表达降低，抑制 caspase 活化和阻断 caspase 介导的病毒核糖核蛋白 (viralribonucleoproteins) 的核输出。 |
| IC50和靶点: | [{name:"p65:200 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Leban, J., Baierl, M., Mies, J., et al.A novel class of potent NF-κB signaling inhibitorsBioorg. Med. Chem. Lett.17(21),5858-5862(2007)
Ehrhardt, C., Rückle, A., Hrincius, E.R., et al.The NF-κB inhibitor SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistanceCell. Microbiol.15(7),1198-1211(2013)
Haasbach, E., Reiling, S.J., Ehrhardt, C., et al.The NF-κB inhibitor SC75741 protects mice against highly pathogenic avian influenza A virusAntiviral Res.99(3),336-344(2013)
