Helenalin
Cat. No.：YN410025
| 产品名称: | Helenalin |
| CAS No.: | 6754-13-8 |
| Chemical Name: | 3,3aS,4S,4aR,7aR,8R,9,9aR-octahydro-4-hydroxy-4a,8-dimethyl-3-methylene-azuleno[6,5-b]furan-2,5-dione |
| Synonyms: | NSC 85236 |
| 分子量: | 262.30 |
| 分子式: | C₁₅H₁₈O₄ |
| SMILES: | O[C@H]1[C@]2([H])C(C(O[C@@]2(C[C@H]([C@@]([H])([C@]13C)C=CC3=O)C)[H])=O)=C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Helenalin 是一种抗炎的倍半萜内酯。Helenalin 通过直接靶向 p65 选择性抑制转录因子NF-κB。Helenalin 具有烷基化活性，以 NF-κB 的 p65 亚基中的半胱氨酸巯基为靶点，从而抑制其 DNA 结合。 |
| IC50和靶点: | |
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Lyss, G., Knorre, A., Schmidt, T.J., et al.The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-κB by directly targeting p65J. Biol. Chem.273(50),33508-33516(1998)
Jin, F., Liu, X., Zhou, Z., et al.Activation of nuclear factor-κB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cellsCancer Res.65(14),6354-6363(2005)
Fernandes, K.M., Auld, C.A., Hopkins, R.G., et al.Helenalin-mediated post-transcriptional regulation of p21(Cip1) inhibits 3T3-L1 preadipocyte proliferationJ. Cell. Biochem.105(3),913-921(2008)
Zhao, L., Lee, J.Y., and Hwang, D.H.Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicalsNutr. Rev.69(6),310-320(2011)
Lim, C.B., Fu, P.Y., Zhu, H.S., et al.NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell deathBMC Complement. Altern. Med.12,1-12(2012)
Schmidt, T.J., Nour, A.M.M., Khalid, S.A., et al.Quantitative structure-antiprotozoal activity relationships of sesquiterpene lactonesMolecules14(6),2062-2076(2009)
Boulanger, D., Brouillette, E., Jaspar, F., et al.Helenalin reduces Staphylococcus aureus infection in vitro and in vivoVet. Microbiol.119,330-338(2007)
