Gossypin
Cat. No.：YN410032
| 产品名称: | Gossypin |
| CAS No.: | 652-78-8 |
| Chemical Name: | 2-(3,4-dihydroxyphenyl)-8-(β-D-glucopyranosyloxy)-3,5,7-trihydroxy-4H-1-benzopyran-4-one |
| Synonyms: | |
| 分子量: | 480.38 |
| 分子式: | C₂₁H₂₀O₁₃ |
| SMILES: | O=C1C(O)=C(C2=CC=C(O)C(O)=C2)OC3=C(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)C(O)=CC(O)=C13 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Gossypin 是从Hibiscus vitifolius中分离得到的一种黄酮，具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病、镇痛和保护肝脏的活性。Gossypin 抑制NF-κB和 NF-κB 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中，Gossypin 也可抑制 RANKL 诱导的破骨细胞形成。 |
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Kunnumakkara, A.B., Nair, A.S., Ahn, K.S., et al.Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-κB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesisBlood109(12),5112-5121(2007)
Jung, Y., Shin, S.Y., Yong, Y., et al.Plant-derived flavones as inhibitors of aurora B kinase and their quantitative structure-activity relationshipsChem. Biol. Drug Des.85(5),574-585(2015)
Wang, L., Wang, X., Chen, H., et al.Gossypin inhibits gastric cancer growth by direct targeting of AURKA and RSK2Phytother. Res.33(3),640-650(2019)
Yoon, I., Lee, K.H., and Cho, J.Gossypin protects primary cultured rat cortical cells from oxidative stress- and beta-amyloid-induced toxicityArch. Pharm. Res.27(4),454-459(2004)
Viswanathan, S., Sambantham, P.T., Reddy, K., et al.Gossypin-induced analgesia in miceEur. J. Pharmacol.98(2),289-291(1984)
