SP-8356
Cat. No.：YN410040
CAS No. ：1454885-45-0
| 产品名称: | SP-8356 |
| CAS No.: | 1454885-45-0 |
| Chemical Name: | (1S,5R)-4-[(1E)-2-(3,4-dihydroxy-5-methoxyphenyl)ethenyl]-6,6-dimethyl-bicyclo[3.1.1]hept-3-en-2-one |
| Synonyms: | |
| 分子量: | 300.35 |
| 分子式: | C₁₈H₂₀O₄ |
| SMILES: | O=C1[C@](C2)([H])C(C)(C)[C@]2([H])C(/C=C/C3=CC(OC)=C(O)C(O)=C3)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SP-8356，一种合成的抗炎的 Verbenone 衍生物，是一种有效的、口服活性的分化 147(CD147)抑制剂。SP-835 抑制 CD147-环磷酰胺 A (CypA) 相互作用，降低 MMP-9 活性。SP-8356 通过抑制NF-κB信号传导发挥抗乳腺癌作用。具有抗动脉粥样硬化作用。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Pahk, K., Noh, H., Joung, C., et al.A novel CD147 inhibitor, SP-8356, reduces neointimal hyperplasia and arterial stiffness in a rat model of partial carotid artery ligationJ. Transl. Med.17(1),274(2019)
Pahk, K., Joung, C., Song, H.Y., et al.SP-8356, a novel inhibitor of CD147-cyclophilin A interactions, reduces plaque progression and stabilizes vulnerable plaques in apoE-deficient miceInt. J. Mol. Sci.21(1),95(2019)
Ju, C., Song, S., Hwang, S., et al.Discovery of novel (1S)-(‒)-verbenone derivatives with anti-oxidant and anti-ischemic effectsBioorg. Med. Chem. Lett.23(19),5421-5425(2013)
Mander, S., Kim, D.H., Nguyen, H.T., et al.SP-8356, a (1S)-(‒)-verbenone derivative, exerts in vitro and in vivo anti-breast cancer effects by inhibiting NF-κB signalingSci. Rep.9(1),6595(2019)
