CBL0137 hydrochloride
Cat. No.：YN410077
CAS No. ：1197397-89-9
| 产品名称: | CBL0137 hydrochloride |
| CAS No.: | 1197397-89-9 |
| Chemical Name: | 1,1'-[9-[2-[(1-methylethyl)imino]ethyl]-9H-carbazole-3,6-diyl]bis-ethanone, monohydrochloride |
| Synonyms: | Curaxin-137 hydrochloride; CBL-C137 hydrochloride |
| 分子量: | 372.89 |
| 分子式: | C₂₁H₂₅ClN₂O₂ |
| SMILES: | CC(NCCN1C2=C(C3=C1C=CC(C(C)=O)=C3)C=C(C(C)=O)C=C2)C.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CBL0137 hydrochloride 是组蛋白分子伴侣FACT的抑制剂。CBL0137 hydrochlorideye 也可以激活p53并抑制NF-κB，对于它们的EC50值分别为 0.37 和 0.47 μM。 |
| IC50和靶点: | [{name:"p53:0.37 μM (IC50)"},{name: "NF-κB:0.47 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Gasparian, A.V., Burkhart, C.A., Purmal, A.A., et al.Curaxins: Anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACTSci. Transl. Med.3(95),(2011)
Burkhart, C., Fleyshman, D., Kohrn, R., et al.Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancerOncotarget5(22),11038-11053(2014)
