Triptolide
Cat. No.：YN410081
| 产品名称: | Triptolide |
| CAS No.: | 38748-32-2 |
| Chemical Name: | 3bS,4,4aS,6R,6aR,7aS,7bS,8bS,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-trisoxireno[4b,5aS:6,7:8aS,9]phenanthro[1,2-c]furan-1(3H)-one |
| Synonyms: | 雷公藤多甙; PG490 |
| 分子量: | 360.40 |
| 分子式: | C₂₀H₂₄O₆ |
| SMILES: | C[C@@]12[C@@]34[C@](O5)([C@@H]([C@](O6)(C(C)C)[C@@H]6[C@@H]3O4)O)[C@@H]5C[C@@]1([H])C7=C(C(OC7)=O)CC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Triptolide是从雷公藤根中提取的二萜类三环氧化物，具有免疫抑制，抗炎和抗增殖作用。 雷公藤内酯是NF-κB活化的抑制剂。 |
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Corson, T.W., Cavga, H., Aberle, N., et al.Triptolide directly inhibits dCTP pyrophosphataseChembiochem12(11),1767-1773(2011)
Song, J.M., Molla, K., Anandharaj, A., et al.Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signalingOncotarget.8(16),26927-26940(2017)
Tang, B., Zhu, J., Zhang, B., et al.Therapeutic potential of triptolide as an anti-inflammatory agent in dextran sulfate sodium-induced murine experimental colitisFront. Immunol.11,592084(2020)
Yang, S.-X., Gao, H.-L., Xie, S.-S., et al.Immunosuppression of triptolide and its effect on skin allograft survivalInt. J. Immunopharmacol.14(6),963-969(1992)
