(R)-(-)-Ibuprofen
Cat. No.：YN410083
| 产品名称: | (R)-(-)-Ibuprofen |
| CAS No.: | 51146-57-7 |
| Chemical Name: | αR-methyl-4-(2-methylpropyl)-benzeneacetic acid |
| Synonyms: | (R)-(-)-布洛芬; (R)-Ibuprofen |
| 分子量: | 206.28 |
| 分子式: | C₁₃H₁₈O₂ |
| SMILES: | C[C@H](C1=CC=C(CC(C)C)C=C1)C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (R)-(-)-Ibuprofen 是 Ibuprofen 的 R 型异构体，对 COX 无作用，可以抑制NF-κB的活化；(R)-(-)-Ibuprofen 具有抗炎和镇痛的作用。 |
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Scheuren, N., Bang, H., Münster, T., et al.Modulation of transcription factor NF-κB by enantiomers of the nonsteroidal drug ibuprofenBr. J. Pharmacol.123(4),645-652(1998)
Villanueva, M., Heckenberger, R., Strobach, H., et al.Equipotent inhibition by R(-)-, S(+)- and racemic ibuprofen of human polymorphonuclear cell function in vitroBr. J. Clin. Pharmacol.35(3),235-242(1993)
Jeffrey, P., Tucker, G.T., Bye, A., et al.The site of inversion of R(–)-ibuprofen: Studies using rat in-situ isolated perfused intestine/liver preparationsJ. Pharm. Pharmacol.43(10),715-720(1991)
