Parthenolide
Cat. No.：YN410092
| 产品名称: | Parthenolide |
| CAS No.: | 20554-84-1 |
| Chemical Name: | 2,3,6,7,7aS,8,10aS,10bR-octahydro-1aR,5-dimethyl-8-methylene-(4E)-oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one |
| Synonyms: | 小白菊内酯; (-) |
| 分子量: | 248.32 |
| 分子式: | C₁₅H₂₀O₃ |
| SMILES: | C/C1=C\CC[C@@](C)(O2)[C@H]2[C@@H](OC(C3=C)=O)[C@H]3CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Parthenolide是在药草短舌匹菊中发现的倍半萜内酯。 Parthenolide通过抑制NF-κB活化而表现出抗炎活性; 它还可抑制HDAC1蛋白而不影响其他I/II类HDAC。 |
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Tiuman, T.S., Ueda-Nakamura, T., Cortez, D.A.G., et al.Antileishmanial activity of parthenolide, a sesquiterpene lactone isolated from Tanacetum partheniumAntimicrob. Agents Chemother.49(1),176-182(2005)
Guzman, M.L., Rossi, R.M., Karnischky, L., et al.The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cellsBlood105,4163-4169(2005)
Pajak, B., Orzechowski, A., and Gajkowska, B.Molecular basis of parthenolide-dependent proapoptotic activity in cancer cellsFolia Histochem. Cytobiol.46(2),129-135(2008)
Lopez-Franco, O., Hernandez-Vargas, P., Ortiz-Munoz, G., et al.Parthenolide modulates the NF-κB-mediated inflammatory responses in experimental atherosclerosisArterioscler. Thromb. Vasc. Biol.26,1864-1870(2006)
Zhao, L., Lee, J.Y., and Hwang, D.H.Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicalsNutr. Rev.69(6),310-320(2011)
