Aconine
Cat. No.：YN410099
| 产品名称: | Aconine |
| CAS No.: | 509-20-6 |
| Chemical Name: | (1α,3α,6α,14α,15α,16β)-20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane-3,8,13,14,15-pentol |
| Synonyms: | 乌头原碱; Jesaconine |
| 分子量: | 499.59 |
| 分子式: | C₂₅H₄₁NO₉ |
| SMILES: | O[C@@H]1C[C@H](OC)[C@@]23[C@]([H])(C4)[C@]5([H])[C@@H](O)[C@@]4(O)[C@@H](OC)[C@H](O)[C@]5(O)[C@H]6[C@H](OC)[C@@]([H])2[C@]1(COC)CN(CC)[C@H]63 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Aconine 抑制核因子 κB 受体活化剂配体诱导的NF-κB激活。 |
| IC50和靶点: | |
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Wada, K., Nihira, M., and Ohno, Y.Effects of chronic administrations of aconitine on body weight and rectal temperature in miceJ. Ethnopharmacol.105(1-2),89-94(2006)
Zeng, X.-Z., He, L.-G., Wang, S., et al.Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-κB and NFATc1 activation and DC-STAMP expressionActa Pharmacol. Sin.37(2),255-263(2016)
Li, T.-F., Gong, N., and Wang, Y.-X.Ester hydrolysis differentially reduces aconitine-induced anti-hypersensitivity and acute neurotoxicity: Involvement of spinal microglial dynorphin expression and implications for aconitum processingFront. Pharmacol.7:367,(2016)
