Aristolochic acid A
Cat. No.：YN410107
| 产品名称: | Aristolochic acid A |
| CAS No.: | 313-67-7 |
| Chemical Name: | 8-methoxy-6-nitro-phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid |
| Synonyms: | Aristolochic acid I; TR 1736 |
| 分子量: | 341.27 |
| 分子式: | C₁₇H₁₁NO₇ |
| SMILES: | OC(C1=CC2=C(OCO2)C3=C4C(C(OC)=CC=C4)=CC([N+]([O-])=O)=C31)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Aristolochic acid A (Aristolochic acid I; TR 1736) 是植物提取物 Aristolochic acids 的主要成分，其存在于 Aristolochia 和Asarum草本植物中。Aristolochic acid A 显着降低激活蛋白1 (AP-1) 和NF-κB活性。Aristolochic acid A 降低人细胞中膀胱癌相关BLCAP基因表达。 |
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Rosenthal, M.D., Vishwanath, B.S., and Franson, R.C.Effects of aristolochic acid on phospholipase A2 activity and arachidonate metabolism of human neutrophilsBiochim. Biophys. Acta1001(1),1-8(1989)
Vishwanath, B.S., Fawzy, A.A., and Franson, R.C.Edema-inducing activity of phospholipase A2 purified from human synovial fluid and inhibition by aristolochic acidInflammation12(6),549-561(1988)
Vishwanath, B.S., Kini, R.M., and Gowda, T.V.Characterization of three edema-inducing phospholipase A2 enzymes from habu (Trimeresurus Flavoviridis) venom and their interaction with the alkaloid aristolochic acidToxicon25(5),501-515(1987)
Aydin, S., Ambroise, J., Cosyns, J.-P., et al.TP53 mutations in p53-negative dysplastic urothelial cells from Belgian AAN patients: New evidence for aristolochic acid-induced molecular pathogenesis and carcinogenesisMutat. Res.818,17-26(2017)
