Sauchinone
Cat. No.：YN410112
| 产品名称: | Sauchinone |
| CAS No.: | 177931-17-8 |
| Chemical Name: | (5aR,7R,8S,8aR,14aS,14bR)-5a,6,7,8,8a,14b-hexahydro-7,8-dimethyl-5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one |
| Synonyms: | 三白草酮 |
| 分子量: | 356.37 |
| 分子式: | C₂₀H₂₀O₆ |
| SMILES: | C[C@@H]([C@@H](C[C@]12[H])C)[C@](C(C=C(OCO3)C3=C4)=C4O5)([H])[C@@]1([H])[C@]5(OCO6)C6=CC2=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sauchinone 是一种非对映异构的木脂素，从Saururus chinensis中获得。Sauchinone 通过抑制I-κBα磷酸化和p65核易位来抑制 LPS 诱导的 iNOS，TNF-α 和 COX-2 表达。 Sauchinone 具有抗炎和抗氧化活性。 |
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Lee, A.K., Sung, S.H., Kim, Y.C., et al.Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-α and COX-2 expression by sauchinone effects on I-κBα phosphorylation, C/EBP and AP-1 activationBr. J. Pharmacol.139,11-20(2003)
Jung, M.H., Song, M.C., Bae, K., et al.Sauchinone attenuates oxidative stress-induced skeletal muscle myoblast damage through the down-regulation of ceramideBiol. Pharm. Bull.34(4),575-579(2011)
Kim, Y.W., Lee, S.M., Shin, S.M., et al.Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injuryFree Radic. Biol. Med.47(7),1082-1092(2009)
Kim, S.J., Jeong, C.W., Bae, H.B., et al.Protective effect of sauchinone against regional myocardial ischemia/reperfusion injury: inhibition of p38 MAPK and JNK death signaling pathwaysJ. Korean Med. Sci.27(5),572-575(2012)
Bhandari, K., Srivastava, S., and Shankar, G.Synthesis of tetrahydronaphthyl thioureas as potent appetite suppressantsBioorg. Med. Chem.12(15),4189-4196(2004)
