Sanggenon C
Cat. No.：YN410113
| 产品名称: | Sanggenon C |
| CAS No.: | 80651-76-9 |
| Chemical Name: | (5aR,10aS)-2-[(1S,5S,6R)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-buten-1-yl)-11H-benzofuro[3,2-b][1]benzopyran-11-one |
| Synonyms: | 桑根酮 C |
| 分子量: | 708.71 |
| 分子式: | C₄₀H₃₆O₁₂ |
| SMILES: | C/C(C)=C/C[C@](C1=CC=C(O)C=C1O2)(OC3=CC(O)=C([C@@H](C=C(C)C[C@@H]4C(C=CC(O)=C5)=C5O)[C@@H]4C(C(C=CC(O)=C6)=C6O)=O)C(O)=C3C7=O)[C@]27O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sanggenon C 是一种黄烷酮 Diels-Alder 加合物化合物，从桑属 (Morus cathayana) 的根皮中分离出来的。 Sanggenon C 通过抑制钙调神经磷酸酶 /NFAT2途径对心脏肥大和纤维化发挥保护作用。 Sanggenon C 通过抑制NF-κB活性，抑制 RAW264.7 细胞中诱导型一氧化氮合酶的表达，以及肿瘤坏死因子-α 刺激的细胞粘附和血管细胞粘附分子-1 的表达。 Sanggenon C 具有抗氧化和抗炎作用，也有抑制胰脂肪酶 (PL) 作用，IC50为 3. |
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Li, L.-C., Shen, F., Hou, Q., et al.Inhibitory effect and mechanism of action of sanggenon C on human polymorphonuclear leukocyte adhesion to human synovial cellsActa Pharmacol. Sin.23(2),138-142(2002)
Chen, L.-D., Liu, Z.-H., Zhang, L.-F., et al.Sanggenon C induces apoptosis of colon cancer cells via inhibition of NO production, iNOS expression and ROS activation of the mitochondrial pathwayOncol. Rep.38(4),2123-2131(2017)
Wang, H., Feng, T., Guo, D., et al.Sanggenon C stimulates osteoblastic proliferation and differentiation, inhibits osteoclastic resorption, and ameliorates prednisone-induced osteoporosis in zebrafish modelMolecules23(9),E2343(2018)
Xiao, L., Gu, Y., Gao, L., et al.Sanggenon C protects against pressure overload‑induced cardiac hypertrophy via the calcineurin/NFAT2 pathwayMol. Med. Rep.16(4),5338-5346(2017)
