Withaferin A
Cat. No.：YN410129
| 产品名称: | Withaferin A |
| CAS No.: | 5119-48-2 |
| Chemical Name: | 5β,6β-epoxy-4β,22R,27-trihydroxy-1-oxo-δ-lactone-ergosta-2,24-dien-26-oic acid |
| Synonyms: | 醉茄素A |
| 分子量: | 470.60 |
| 分子式: | C₂₈H₃₈O₆ |
| SMILES: | C[C@]([C@](CC[C@@]1(C)[C@@]2([H])CC[C@]1([H])[C@@H]([C@@](O3)([H])CC(C)=C(CO)C3=O)C)([H])[C@@]2([H])C4)(C(C=C5)=O)[C@@]6([C@H]5O)[C@@H]4O6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Withaferin A 是从南非醉茄中分离到的甾体内酯，可以抑制NF-kB的活性，靶作用于波形蛋白 (vimentin)，具有抗炎，抗肿瘤等功效。Withaferin A 是内皮蛋白 C 受体(EPCR)脱落的抑制剂。 |
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Bargagna-Mohan, P., Hamza, A., Kim, Y.e., et al.The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentinChem. Biol.14(6),623-634(2007)
Grin, B., Mahammad, S., Wedig, T., et al.Withaferin A alters intermediate filament organization, cell shape and behaviorPLoS One7(6),1-13(2012)
Hassannia, B., Wiernicki, B., Ingold, I., et al.Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastomaJ. Clin. Invest.128(8),3341-3355(2018)
