Obtusifolin
Cat. No.：YN410130
| 产品名称: | Obtusifolin |
| CAS No.: | 477-85-0 |
| Chemical Name: | 2,8-dihydroxy-1-methoxy-3-methyl-9,10-anthracenedione |
| Synonyms: | 决明蒽醌 |
| 分子量: | 284.26 |
| 分子式: | C₁₆H₁₂O₅ |
| SMILES: | O=C1C2=C(C=CC=C2O)C(C3=CC(C)=C(O)C(OC)=C13)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Obtusifolin 是从决明子的种子中分离出，通过抑制NF-kB通路来调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。Obtusifolin 通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。 |
| IC50和靶点: | |
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Nam, J.H., Seol, D.-W., Lee, C.-G., et al.Obtusifolin, an anthraquinone extracted from Senna obtusifolia (L.) H.S.Irwin & Barneby, reduces inflammation in a mouse osteoarthritis modelPharmaceuticals (Basel)14(3),249(2021)
Tang, Y., and Zhong, Z.Obtusifolin treatment improves hyperlipidemia and hyperglycemia: Possible mechanism involving oxidative stressCell Biochem. Biophys.70(3),1751-1757(2014)
He, Z.-W., Wei, W., Li, S.-P., et al.Anti-allodynic effects of obtusifolin and gluco-obtusifolin against inflammatory and neuropathic painBiol. Pharm. Bull.37(10),1606-1616(2014)
