Sciadopitysin
Cat. No.：YN410131
| 产品名称: | Sciadopitysin |
| CAS No.: | 521-34-6 |
| Chemical Name: | 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one |
| Synonyms: | 金松双黄酮 |
| 分子量: | 580.54 |
| 分子式: | C₃₃H₂₄O₁₀ |
| SMILES: | O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(OC)C=C6O5)=O)=CC=C4OC)C(O)=CC(O)=C13 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sciadopitysin 是一种来自银杏叶片中的双黄酮类化合物。Sciadopitysin 通过抑制NF-κB活化并降低c-Fos和NFATc1的表达来抑制 RANKL 诱导的破骨细胞生成和骨丢失。 |
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Briançon-Scheid, F., Lobstein-Guth, A., and Anton, R.HPLC separation and quantitative determination of biflavones in leaves from ginkgo bilobaPlanta Med.49(12),204-207(1983)
Sasaki, H., Kitoh, Y., Tsukada, M., et al.Inhibitory activities of biflavonoids against amyloid-β peptide 42 cytotoxicity in PC-12 cellsBioorg. Med. Chem.25(14),2831-2833(2015)
Suh, K.S., Chon, S., and Choi, E.M.The protective effects of sciadopitysin against methylglyoxal-induced cytotoxicity in cultured pancreatic β-cellsJ. Appl. Toxicol.38(8),1104-1111(2018)
Cao, J., Lu, Q., Liu, N., et al.Sciadopitysin suppresses RANKL-mediated osteoclastogenesis and prevents bone loss in LPS-treated miceInt. Immunopharmacol.49,109-117(2017)
Bai, J., Zhao, S., Fan, X., et al.Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure-activity relationshipsToxicol. Appl. Pharmacol.369,49-59(2019)
