Bumetanide D5
Cat. No.：YN360625
| 产品名称: | Bumetanide D5 |
| CAS No.: | 1216739-35-3 |
| Chemical Name: | 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-d5-benzoic acid |
| Synonyms: | |
| 分子量: | 369.45 |
| 分子式: | C₁₇H₁₅D₅N₂O₅S |
| SMILES: | O=C(O)C1=CC(NCCCC)=C(OC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C(S(=O)(N)=O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bumetanide D5 是 Bumetanide 的氘代物。Bumetanide 是一种 Na+-K+-Cl-协同转运蛋白 1 (NKCC1) 抑制剂，对 NKCC2 的抑制作用较弱，对 hNKCC1A 和 hNKCC2A 的IC50值分别为 0.68 和 4.0 μM。 |
| IC50和靶点: | |
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Lykke, K., Töllner, K., Feit, P.W., et al.The search for NKCC1-selective drugs for the treatment of epilepsy: Structure-function relationship of bumetanide and various bumetanide derivatives in inhibiting the human cation-chloride cotransporter NKCC1AEpilepsy Behav.59,42-49(2016)
Yang, Y., Fu, A., Wu, X., et al.GPR35 is a target of the loop diuretic drugs bumetanide and furosemidePharmacology89(1-2),13-17(2012)
Temperini, C., Cecchi, A., Scozzafava, A., et al.Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adductBioorg. Med. Chem. Lett.18(8),2567-2573(2008)
Cohen, M.R., Hinsch, E., Vergona, R., et al.A comparative diuretic and tissue distribution study of bumetanide and furosemide in the dogJ. Pharmacol. Exp. Ther.197(3),697-702(1976)
O'Donnell, M.E., Tran, L., Lam, T.I., et al.Bumetanide inhibition of the blood-brain barrier Na-K-Cl cotransporter reduces edema formation in the rat middle cerebral artery occlusion model of strokeJ. Cereb. Blood Flow Metab.24(9),1046-1056(2004)
