PPADS tetrasodium
Cat. No.：YN360066
| 产品名称: | PPADS tetrasodium |
| CAS No.: | 192575-19-2 |
| Chemical Name: | 4-[2-[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]diazenyl]-1,3-benzenedisulfonic acid, tetrasodium salt |
| Synonyms: | |
| 分子量: | 599.30 |
| 分子式: | C₁₄H₁₀N₃Na₄O₁₂PS₂ |
| SMILES: | O=S(C1=CC=C(/N=N/C2=NC(C)=C(O)C(C=O)=C2COP(O[Na])(O[Na])=O)C(S(=O)(O[Na])=O)=C1)(O[Na])=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PPADS tetrasodiuma 是一种非选择性P2X受体拮抗剂。PPADS tetrasodiuma 阻断重组P2X1、-2、-3、-5，IC50范围为1～2.6 μM。PPADS-tetrasodiuma 阻断天然 P2Y2 样 (IC50~0.9 mM) 和重组 P2Y4 (IC50~15 mM) 受体。PPADS tetrasodiuma 是豚鼠气道平滑肌 Na/Ca²⁺ 交换逆模式的抑制剂。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Lambrecht, G., Friebe, T., Grimm, U., et al.PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responsesEur. J. Pharmacol.217(2-3),217-219(1992)
Lämmer, A.B., Beck, A., Grummich, B., et al.The P2 receptor antagonist PPADS supports recovery from experimental stroke in vivoPLoS One6(5),(2011)
