KB-R7943 mesylate
Cat. No.：YN360536
| 产品名称: | KB-R7943 mesylate |
| CAS No.: | 182004-65-5 |
| Chemical Name: | carbamimidothioic acid, 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester, monomethanesulfonate |
| Synonyms: | KB-R7943 |
| 分子量: | 427.50 |
| 分子式: | C₁₇H₂₁N₃O₆S₂ |
| SMILES: | NC(SCCC1=CC=C(OCC2=CC=C([N+]([O-])=O)C=C2)C=C1)=N.CS(=O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KB-R7943 mesylate 是一种Na+/Ca2+交换体(NCXrev) 反向抑制剂，IC50为 5.7±2.1 µM。KB-R7943 mesylate 通过激活JNK通路和抑制自噬通量来诱导癌细胞死亡. |
| IC50和靶点: | |
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| Solvent & Solubility: |
Iwamoto, T., Watano, T., and Shigekawa, M.A novel isothiourea derivative selectively inhibits the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1J. Biol. Chem.271(37),22391-22397(1996)
Brustovetsky, T., Brittain, M.K., Sheets, P.L., et al.KB-R7943, an inhibitor of the reverse Na+/Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex IBr. J. Pharmacol.162(1),255-270(2011)
Wu, X., Eder, P., Chang, B., et al.TRPC channels are necessary mediators of pathologic cardiac hypertrophyProc. Natl. Acad. Sci. USA107(15),7000-7005(2010)
