SEA0400
Cat. No.：YN360545
CAS No. ：223104-29-8
| 产品名称: | SEA0400 |
| CAS No.: | 223104-29-8 |
| Chemical Name: | 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxy-benzenamine |
| Synonyms: | 2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺,SEA 0400,SEA-0400 |
| 分子量: | 371.38 |
| 分子式: | C₂₁H₁₉F₂NO₃ |
| SMILES: | NC1=CC(OCC)=CC=C1OC2=CC=C(OCC3=CC(F)=CC=C3F)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SEA0400 是一种新颖的，具有选择性的Na+-Ca2+exchanger抑制剂，在培养的神经元、星形胶质细胞和小胶质细胞中，能够抑制 Na+-依赖性 Ca2+的吸收，IC50值为 5-33 nM。 |
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Matsuda, T., Arakawa, N., Takuma, K., et al.SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic modelsJ. Pharmacol. Exp. Ther.298(1),249-256(2001)
Nashida, T., Takuma, K., Fukuda, S., et al.The specific Na+/Ca2+ exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cellsNeurochem.Int.59(1),51-58(2011)
Ago, Y., Kawasaki, T., Nashida, T., et al.SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's diseaseNeuropharmacology61(8),1441-1451(2011)
