Benzamil hydrochloride
Cat. No.：YN360877
CAS No. ：161804-20-2
| 产品名称: | Benzamil hydrochloride |
| CAS No.: | 161804-20-2 |
| Chemical Name: | 3,5-diamino-6-chloro-N-[imino[(phenylmethyl)amino]methyl]-2-pyrazinecarboxamide, monohydrochloride |
| Synonyms: | Benzylamiloride hydrochloride |
| 分子量: | 356.21 |
| 分子式: | C₁₃H₁₅Cl₂N₇O |
| SMILES: | O=C(C1=NC(Cl)=C(N)N=C1N)NC(NCC2=CC=CC=C2)=N.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Benzamil hydrochloride (Benzylamiloride hydrochloride)，是 Amiloride 类似物，是一种 Na+/Ca2+交换体(NCX)抑制剂 (IC50~100 nM)。Benzamil hydrochloride 也是一种非选择性Deg/epithelial sodium channels (ENaC)阻滞剂，能增强肌源性血管收缩。Benzamil hydrochloride 抑制 TRPP3 介导的 Ca2+激活电流，IC50为 1.1 μM。 |
| IC50和靶点: | |
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Kleyman, T.R., Yulo, T., Ashbaugh, C., et al.Photoaffinity labeling of the epithelial sodium channelJ. Biol. Chem.261(6),2839-2843(1986)
Fischer, K.-G., Jonas, N., Poschenrieder, F., et al.Characterization of a Na+-Ca2+ exchanger in podocytesNephrol. Dial. Transplant.17(10),1742-1750(2002)
Dai, X.Q., Ramji, A., Liu, Y., et al.Inhibition of TRPP3 channel by amiloride and analogsMol. Pharmacol.72(6),1576-1585(2007)
