S0859
Cat. No.：YN360547
| 产品名称: | S0859 |
| CAS No.: | 1019331-10-2 |
| Chemical Name: | 2-chloro-N-[[2'-[(cyanoamino)sulfonyl][1,1'-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]-benzamide |
| Synonyms: | S 0859; S-0859, S 0859; S-0859 |
| 分子量: | 530.04 |
| 分子式: | C₂₉H₂₄ClN₃O₃S |
| SMILES: | O=C(N(CC1=CC=C(C2=CC=CC=C2S(=O)(NC#N)=O)C=C1)CC3=CC=C(C)C=C3)C4=CC=CC=C4Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | S0859 是一种选择性的，高亲和力的NBC抑制剂，可逆性地抑制 NBC 介导的细胞内 pH (pHi) 恢复 (Ki=1.7 μM，完全抑制在 30 μM)。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ch'en, F.F.T., Villafuerte, F.C., Swietach, P., et al.S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heartBr. J. Pharmacol.153,972-982(2008)
Yamamoto, T., Swietach, P., Rossini, A., et al.Functional diversity of electrogenic Na+-HCO3- cotransport in ventricular myocytes from rat, rabbit and guinea pigJ. Physiol.562.2,455-475(2005)
Kumar, S., Flacke, J.P., Kostin, S., et al.SLC4A7 sodium bicarbonate co-transporter controls mitochondrial apoptosis in ischaemic coronary endothelial cellsCardiovasc. Res.89(2),392-400(2011)
Lauritzen, G., Stock, C.M., Lemarie, J., et al.The Na+/H+ exchanger NHE1, but not the Na+, HCO3- cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2Cancer Lett.317(2),172-183(2012)
Orlowski, A., Vargas, L.A., Aiello, E.A., et al.Elevated carbon dioxide upregulates NBCn1 Na+/HCO3- cotransporter in human embryonic kidney cellsAm. J. Physiol. Renal Physiol.305,F1765-F1774(2013)
Giambelluca, M.S., Ciancio, M.C., Orlowski, A., et al.Characterization of the Na/HCO3- cotransport in human neutrophilsCell. Physiol. Biochem.33(4),982-990(2014)
