Bafilomycin C1
Cat. No.：YN360399
| 产品名称: | Bafilomycin C1 |
| CAS No.: | 88979-61-7 |
| Chemical Name: | 2E-butenedioic acid-1-[(2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethyl)- |
| Synonyms: | 巴菲霉素C1 |
| 分子量: | 720.89 |
| 分子式: | C₃₉H₆₀O₁₂ |
| SMILES: | C[C@H]([C@@](C[C@H]([C@@H]1C)OC(/C=C/C(O)=O)=O)(O[C@@H]1C(C)C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C/[C@H]2C)=O)([H])[C@H](/C=C/C=C(C[C@@H]([C@@H]2O)C)\C)OC)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bafilomycin C1 是从链霉菌中分离得到的大环内酯类抗生素 (antibiotic)。Bafilomycin C1 是一种有效的、特异性的、可逆的vacuolar-type H+-ATPases抑制剂。Bafilomycin C1 抑制革兰氏阳性菌 (bacteria) 和真菌 (fungi) 的生长。Bafilomycin C1 可诱导细胞凋亡 (apoptosis)，可用于肝细胞癌 (HCC) 的研究。 |
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Papini, E., de Bernard, M., Bugnoli, M., et al.Cell vacuolization induced by Helicobacter pylori: Inhibition by bafilomycins A1, B1, C1 and DFEMS Microbiol. Lett.113(2),155-159(1993)
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Werner, G., Hagenmaier, H., Drautz, H., et al.Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activityJ. Antibiot.37(2),110-117(1984)
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Xie, X., Lu, S., Pan, X., et al.Antiviral bafilomycins from a feces-inhabiting Streptomyces sp.J. Nat. Prod.84(2),537-543(2021)
