Oleandrin
Cat. No.：YN360463
| 产品名称: | Oleandrin |
| CAS No.: | 465-16-7 |
| Chemical Name: | (3β,5β,16β)-16-(acetyloxy)-3-[(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)oxy]-14-hydroxy-card-20(22)-enolide |
| Synonyms: | 欧夹竹桃苷 |
| 分子量: | 576.72 |
| 分子式: | C₃₂H₄₈O₉ |
| SMILES: | O=C1OCC([C@H]2[C@@H](OC(C)=O)C[C@]3(O)[C@]4([H])CC[C@]5([H])C[C@@H](O[C@H]6C[C@@H]([C@H]([C@H](C)O6)O)OC)CC[C@]5(C)[C@@]4([H])CC[C@]23C)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Oleandrin 抑制Na+, K+-ATPase活性，IC50为 620 nM。Oleandrin 通过激活内质网应激诱导细胞凋亡。 |
| IC50和靶点: | |
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Manna, S.K., Sah, N.K., Newman, R.A., et al.Oleandrin suppresses activation of nuclear transcription factor-κB, activator protein-1, and c-Jun NH2-terminal kinaseCancer Res.60(14),3838-3847(2000)
Yang, C.-W., Chang, H.-Y., Hsu, H.-Y., et al.Identification of anti-viral activity of the cardenolides, Na+/K+-ATPase inhibitors, against porcine transmissible gastroenteritis virusToxicol. Appl. Pharmacol.332,129-137(2017)
Dunn, D.E., He, D.N., Yang, P., et al.In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice-based stroke modelsJ. Neurochem.119(4),805-814(2011)
Garofalo, S., Grimaldi, A., Chece, G., et al.The glycoside oleandrin reduces glioma growth with direct and indirect effects on tumor cellsJ. Neurosci.37(14),3926-3939(2017)
