Digitoxin
Cat. No.：YN360860
CAS No. ：71-63-6
| 产品名称: | Digitoxin |
| CAS No.: | 71-63-6 |
| Chemical Name: | (3β,5β)-3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxy-card-20(22)-enolide |
| Synonyms: | 洋地黄毒苷 |
| 分子量: | 764.94 |
| 分子式: | C₄₁H₆₄O₁₃ |
| SMILES: | C[C@H]1O[C@](O[C@@H]2[C@@H](C)O[C@](O[C@H]3[C@@H](O)C[C@@](O[C@@H]4C[C@](CC[C@]5([H])[C@]6([H])CC[C@@]7(C)[C@]5(O)CC[C@@H]7C(CO8)=CC8=O)([H])[C@]6(C)CC4)([H])O[C@@H]3C)([H])C[C@@H]2O)([H])C[C@H](O)[C@@H]1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Digitoxin是有效的 Na+/K+-ATPase抑制剂, EC50 值为0.78 μM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Katz, A., Lifshitz, Y., Bab-Dinitz, E., et al.Selectivity of digitalis glycosides for isoforms of human Na,K-ATPaseJ. Biol. Chem.285(25),19582-19592(2010)
Wang, L., Wible, B.A., Wan, X., et al.Cardiac glycosides as novel inhibitors of human ether-a-go-go-related gene channel traffickingJ. Pharmacol. Exp. Ther.320(2),525-534(2007)
Temma, K., Akera, T., and Brody, T.M.Inotropic effects of digitoxin in solated guines-pig heart under conditions which alter contractionEur. J. Pharm.76(4),361-370(1981)
Picollo, C.T., dos Santos, A.A., Antonio, E.L., et al.Digitoxin attenuates heart failure, reduces myocardial hypertrophy, and preserves the calcium-binding proteins in infarcted ratsJ. Cardiovasc. Pharmacol. Ther.25(3),265-272(2019)
Johansson, S., Lindholm, P., Gullbo, J., et al.Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cellsAnticancer Drugs12(5),475-483(2001)
