Ginsenoside Rb1
Cat. No.：YN360904
CAS No. ：41753-43-9
| 产品名称: | Ginsenoside Rb1 |
| CAS No.: | 41753-43-9 |
| Chemical Name: | 20-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12β-hydroxydammar-24-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside |
| Synonyms: | 人参皂苷 Rb1; Gypenoside III |
| 分子量: | 1109.29 |
| 分子式: | C₅₄H₉₂O₂₃ |
| SMILES: | C[C@@]([C@@]12C)(CC[C@@]3([H])C4(C)C)[C@@](C[C@@H](O)[C@]1([H])[C@]([C@@](CC/C=C(C)/C)(C)O[C@@H]([C@@H]([C@@H](O)[C@@H]5O)O)O[C@@H]5CO[C@@H]([C@@H]([C@@H](O)[C@@H]6O)O)O[C@@H]6CO)([H])CC2)([H])[C@]3(CC[C@@H]4O[C@@](O[C@H](CO)[C@@H](O)[C@@H]7O)([H])[C@@H]7 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ginsenoside Rb1 是中药Panax ginseng的成分。Ginsenoside 抑制Na+, K+-ATPase活性，IC50为 6.3±1.0 μM。Ginsenoside Rb1 也抑制IRAK-1激活及NF-κB p65的磷酸化。 |
| IC50和靶点: | [{name:"Na+, K+-ATPase:6.3 μM (IC50)'}, 'IRAK-1', 'p65', 'Autophagy', 'Mitophagy', 'HSV-1'] |
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Wang, X.F., Liu, X.j., Zhou, Q.M., et al.Ginsenoside rb1 reduces isoproterenol-induced cardiomyocytes apoptosis in vitro and in vivoEvid. Based Complement. Alternat. Med.2013,454389(2013)
Liu, D., Zhang, H., Gu, W., et al.Neuroprotective effects of ginsenoside rb1 on high glucose-induced neurotoxicity in primary cultured rat hippocampal neuronsPLoS One8(11),e793399(2013)
Zhao, J., Lu, S., Yu, H., et al.Baicalin and ginsenoside Rb1 promote the proliferation and differentiation of neural stem cells in Alzheimer's disease model ratsBrain Res.1678,187-194(2018)
Joh, E.-H., Lee, I.-A., Jung, I.-H., et al.Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation—the key step of inflammationBiochem. Pharmacol.82(3),278-286(2011)
Yang, X., Dong, B., An, L., et al.Ginsenoside rb1 ameliorates glycemic disorder in mice with high fat diet-induced obesity via regulating gut microbiota and amino acid metabolismFront. Pharmacol.12,756491(2021)
