Phlorizin
Cat. No.：YN360910
| 产品名称: | Phlorizin |
| CAS No.: | 60-81-1 |
| Chemical Name: | 1-[2-(β-D-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone |
| Synonyms: | 根皮苷; Floridzin; NSC 2833 |
| 分子量: | 436.41 |
| 分子式: | C₂₁H₂₄O₁₀ |
| SMILES: | O=C(C1=C(O)C=C(O)C=C1O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)CCC3=CC=C(O)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Phlorizin 是一种非选择性的SGLT抑制剂，对于hSGLT1和hSGLT2的Ki值分别为 300 和 39 nM。Phlorizin 也是一个Na+/K+-ATPase抑制剂。 |
| IC50和靶点: | |
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Chao, E.C., and Henry, R.R.SGLT2 inhibition - A novel strategy for diabetes treatmentNat. Rev. Drug Discov.9(7),551-559(2010)
White, J.R., Jr.Apple trees to sodium glucose co-transporter inhibitors: A review of SGLT2 inhibitionClinical Diabetes28(1),5-10(2010)
Ehrenkranz, J.R.L., Lewis, N.G., Kahn, C.R., et al.Phlorizin: A reviewDiabetes Metab. Res. Rev.21(1),31-38(2005)
Hummel, C.S., Lu, C., Liu, J., et al.Structural selectivity of human SGLT inhibitorsAm. J. Physiol. Cell Physiol.302(2),C373-C382(2012)
Hummel, C.S., Lu, C., Loo, D.D.F., et al.Glucose transport by human renal Na+/d-glucose cotransporters SGLT1 and SGLT2Am. J. Physiol. Cell Physiol.300(1),C14-C21(2011)
