Bufalin
Cat. No.：YN360944
| 产品名称: | Bufalin |
| CAS No.: | 465-21-4 |
| Chemical Name: | (3β,5β)-3,14-dihydroxy-bufa-20,22-dienolide |
| Synonyms: | BF |
| 分子量: | 386.52 |
| 分子式: | C₂₄H₃₄O₄ |
| SMILES: | O[C@]([C@@](CC[C@@]1([H])[C@@]2(CC[C@H](O)C1)C)([H])[C@]2([H])CC3)(CC[C@@H]4C(C=C5)=COC5=O)[C@]34C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bufalin 是蟾酥中的有效活性成分，为有效的Na+/K+-ATPase抑制剂，可与其基 α1, α2 和 α3 结合，Kd值分别为 42.5，45 和 40 nM。具有抗肿瘤活性。 |
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Yoshida, S., and Sakai, T.Effects of bufalin and related cardiotonic steroids in the neuromuscular junctionJpn. J. Pharmacol.23(6),859-869(1973)
Pavlovic, D.The role of cardiotonic steroids in the pathogenesis of cardiomyopathy in chronic kidney diseaseNephron Clin. Pract.128(1-2),11-21(2014)
Katz, A., Lifshitz, Y., Bab-Dinitz, E., et al.Selectivity of digitalis glycosides for isoforms of human Na,K-ATPaseJ. Biol. Chem.285(25),19582-19592(2010)
Hamlyn, J.M.Natriuretic hormones, endogenous ouabain, and related sodium transport inhibitorsFront. Endocrinol. (Lausanne)5,(2015)
Wang, Y., Lonard, D.M., Yu, Y., et al.Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1Cancer Res.74(5),1506-1517(2014)
Wu, S.H., Hsiao, Y.T., Kuo, C.L., et al.Bufalin inhibits NCI-H460 human lung cancer cell metastasis in vitro by inhibiting MAPKs, MMPs, and NF-KB pathwaysAm. J. Chin. Med.43(6),1247-1264(2015)
Yin, P.H., Liu, X., Qiu, Y.Y., et al.Anti-tumor activity and apoptosis-regulation mechanisms of bufalin in various cancers: New hope for cancer patientsAsian Pac. J. Cancer Prev.13(11),5339-5343(2012)
