Sonepiprazole
Cat. No.：YN1730066
CAS No. ：170858-33-0
| 产品名称: | Sonepiprazole |
| CAS No.: | 170858-33-0 |
| Chemical Name: | 4-[4-[2-[(1S)-3,4-dihydro-1H-2-benzopyran-1-yl]ethyl]-1-piperazinyl]-benzenesulfonamide |
| Synonyms: | PNU-101387G; U-101387G |
| 分子量: | 401.52 |
| 分子式: | C₂₁H₂₇N₃O₃S |
| SMILES: | O=S(C1=CC=C(N2CCN(CC[C@H]3C4=CC=CC=C4CCO3)CC2)C=C1)(N)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sonepiprazole (PNU-101387G) 是一种选择性D4多巴胺拮抗剂，对rD4多巴胺，hD4.2多巴胺，rD2多巴胺和组胺H1受体的Ki分别为 3.6、10.1、5147 和 7430 nM。 |
| IC50和靶点: | [{name:"rD2 Receptor:5147 nM (Ki)"},{name: "rD4 Receptor:3.6 nM (Ki)"},{name: "Histamine H1 Receptor:7430 nM (Ki)"}] |
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Merchant, K.M., Gill, G.S., Harris, D.W., et al.Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonistJ. Pharmacol. Exp. Ther.279(3),1392-1403(1996)
Tenbrink, R.E., Bergh, C.L., Duncah, J.N., et al.(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonistJ. Med. Chem.39(13),2435-2437(1996)
Corrigan, M.H., Gallen, C.C., Bonura, M.L., et al.Effectiveness of the selective D4 antagonist sonepiprazole in schizophrenia: A placebo-controlled trialBiol. Psychiatry55(5),445-451(2004)
Arnsten, A.F.T., Murphy, B., and Merchant, K.The selective dopamine D4 receptor antagonist, PNU-101387G, prevents stress-induced cognitive deficits in monkeysNeuropsychopharmacology23(4),405-410(2000)
