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Haloperidol D4

Cat. No.:YN1730070

  • CAS No. :1189986-59-1

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    • 产品名称: Haloperidol D4
      CAS No.: 1189986-59-1
      Chemical Name: 4-(4-(4-chlorophenyl-2,3,5,6-d4)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one
      Synonyms:氟哌啶醇D4
      分子量:379.89
      分子式:C₂₁H₁₉D₄ClFNO₂
      SMILES:ClC1=C([2H])C([2H])=C(C2(O)CCN(CCCC(C3=CC=C(F)C=C3)=O)CC2)C([2H])=C1[2H]
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Haloperidol D4 是 haloperidol 的氘代物。Haloperidol 为dopamine D2 receptor的拮抗剂。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Burstein, E.S., Ma, J., Wong, S., et al.Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: Identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonistJ. Pharmacol. Exp. Ther.315(3),1278-1287(2005)

      Richelson, E., and Souder, T.Binding of antipsychotic drugs to human brain receptors: Focus on newer generation compoundsLife Sci.68(1),29-39(2000)

      Creese, I., Burt, D.R., and Snyder, S.H.Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugsJ. Neuropsychiatry Clin. Neurosci.8(2),223-226(1996)

      Swerdlow, N.R., and Geyer, M.A.Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophreniaPharmacol. Biochem. Behav.44(3),741-744(1993)

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