Thioperamide maleate
Cat. No.：YN1730134
| 产品名称: | Thioperamide maleate |
| CAS No.: | 148440-81-7 |
| Chemical Name: | N-cyclohexyl-4-(1H-imidazol-5-yl)-1-piperidinecarbothioamide, 2Z-butenedioate |
| Synonyms: | MR-12842 maleate |
| 分子量: | 408.5 |
| 分子式: | C15H24N4S • C4H4O4 |
| SMILES: | S=C(NC1CCCCC1)N(CC2)CCC2C3=CN=CN3.O=C(/C=C\C(O)=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Thioperamide maleate (MR-12842 maleate) 是一种有效的，具有口服活性的，可透过血脑屏障的选择性H3受体拮抗剂，抑制 [3H] 组胺释放的Ki为 4.3 nM。Thioperamide maleate 抑制 [3H] 组胺合成的Ki为 31 nM 。 |
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Meir, G., Apelt, J., Reichert, U., et al.Influence of imidazole replacement in different structural classes of histamine H3-receptor antagonistsEur. J. Pharm. Sci.13,249-259(2001)
Harada, C., Fujii, Y., Hirai, T., et al.Inhibitory effect of iodophenpropit, a selective histamine H3 antagonist, on amygdaloid kindled seizuresBrain Res. Bull.63(2),143-146(2004)
