IMR-1
Cat. No.：YN380007
CAS No. ：310456-65-6
| 产品名称: | IMR-1 |
| CAS No.: | 310456-65-6 |
| Chemical Name: | 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid, ethyl ester |
| Synonyms: | IMR-1;IMR1;2-[2-Methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid ethyl ester;Inhibitor of Mastermind Recruitment-1;HMS3886L08;s8280;STK751326;ethyl {2-methoxy-4-[(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}acetate;e |
| 分子量: | 353.41 |
| 分子式: | C₁₅H₁₅NO₅S₂ |
| SMILES: | O=C(OCC)COC1=CC=C(/C=C(SC(N2)=S)\C2=O)C=C1OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IMR-1 是一类新的Notch抑制剂，IC50为 26 μM。IMR-1 阻止 Maml1 募集到染色质上的 Notch 三元复合体 (NTC)，抑制 Notch 靶基因转录并显着抑制患者衍生的肿瘤异种移植模型中的肿瘤生长。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Astudillo, L., Da Silva, T.G., Wang, Z., et al.The small molecule IMR-1 inhibits the Notch transcriptional activation complex to suppress tumorigenesisCancer Res.76(12),3593-3603(2016)
