Valproic acid
Cat. No.：YN380028
| 产品名称: | Valproic acid |
| CAS No.: | 99-66-1 |
| Chemical Name: | 2-propyl-pentanoic acid |
| Synonyms: | 丙戊酸; VPA; 2-Propylpentanoic Acid |
| 分子量: | 144.21 |
| 分子式: | C₈H₁₆O₂ |
| SMILES: | CCCC(CCC)C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Valproic acid (VPA; 2-Propylpentanoic Acid) 是一种HDAC抑制剂，IC50值为 0.5-2 mM，抑制HDAC1的活性，(IC50，400 μM)，同时可诱导HDAC2的降解。Valproic acid 激活Notch1信号并抑制小细胞肺癌 (SCLC) 细胞的增殖。Valproic acid 可用于癫痫、双相情感障碍和偏头痛等的研究。 |
| IC50和靶点: | [{name:"HDAC1:400 μM (IC50)"},{name: "HDAC:0.5-2 mM (IC50)'}, 'HDAC2', 'Autophagy', 'Mitophagy'] |
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Göttlicher, M., Minucci, S., Zhu, P., et al.Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cellsEMBO J.20(24),6969-6978(2001)
Williams, R.S.B., Cheng, L., Mudge, A.W., et al.A common mechanism of action for three mood-stabilizing drugsNature417(6886),292-295(2002)
Qing, H., He, G., Ly, P.T., et al.Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse modelsJ. Exp. Med.205(12),2781-2789(2008)
Elmazar, M.M., Hauck, R.S., and Nau, H.Anticonvulsant and neurotoxic activities of twelve analogues of valproic acidJ. Pharm. Sci.82(12),1255-1258(1993)
