RO4929097
Cat. No.：YN380042
CAS No. ：847925-91-1
| 产品名称: | RO4929097 |
| CAS No.: | 847925-91-1 |
| Chemical Name: | N1-[(7S)-6,7-dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)-propanediamide |
| Synonyms: | RG-4733 |
| 分子量: | 469.40 |
| 分子式: | C₂₂H₂₀F₅N₃O₃ |
| SMILES: | O=C(C(C)(C(NCC(F)(C(F)(F)F)F)=O)C)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RO4929097 (RG-4733) 是一种γ secretase抑制剂，IC50值为 4 nM，能够抑制细胞内 Aβ40 的产生和 Notch 活性，EC50值分别为 14 nM 和 5 nM。 |
| IC50和靶点: | |
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Luistro, L., He, W., Smith, M., et al.Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic propertiesCancer Res.69(19),7620-7680(2009)
Huynh, C., Poliseno, L., Segura, M.F., et al.The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanomaPLoS One6(9),(2011)
