YO-01027
Cat. No.：YN380081
| 产品名称: | YO-01027 |
| CAS No.: | 209984-56-5 |
| Chemical Name: | N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-benzeneacetamide |
| Synonyms: | Dibenzazepine; DBZ |
| 分子量: | 463.48 |
| 分子式: | C₂₆H₂₃F₂N₃O₃ |
| SMILES: | O=C(N[C@@H](C)C(N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C)C1=O)=O)CC4=CC(F)=CC(F)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | YO-01027 (Dibenzazepine; DBZ) 是高效的 γ-分泌酶抑制剂，裂解Notch和APPL的IC50分别为 2.92 和 2.64 nM。 |
| IC50和靶点: | |
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Dovey, H.F., John, V., Anderson, J.P., et al.Functional γ-secretase inhibitors reduce β-amyloid peptide levels in brainJ. Neurochem.76(1),173-181(2001)
Wolfe, M.S.Therapeutic strategies for Alzheimer's diseaseNat. Rev. Drug Discov.1(11),859-866(2002)
Milano, J., McKay, J., Dagenais, C., et al.Modulation of notch processing by γ-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiationToxicol. Sci.82(1),341-358(2004)
