Adenosine dialdehyde
Cat. No.：YN290185
| 产品名称: | Adenosine dialdehyde |
| CAS No.: | 34240-05-6 |
| Chemical Name: | 6-amino-α-(1-formyl-2-hydroxyethoxy)-9H-purine-9-acetaldehyde |
| Synonyms: | 腺苷二醛 |
| 分子量: | 265.23 |
| 分子式: | C₁₀H₁₁N₅O₄ |
| SMILES: | O=CC(OC(C=O)CO)N1C=NC2=C(N)N=CN=C12 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Adenosine Dialdehyde 是嘌呤核苷的类似物，是 S-腺苷同型半胱氨酸水解酶 (SAH) 的不可逆抑制剂 (IC50=40 nM)。Adenosine Dialdehyde 具有较强的抗肿瘤活性，可用于肿瘤研究。 |
| IC50和靶点: | |
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Madhavan, G.V., McGee, D.P., Rydzewski, R.M., et al.Synthesis and antiviral evaluation of 6'-substituted aristeromycins: Potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolaseJ. Med. Chem.31(9),1798-1804(1988)
O'Dea, R.F., Mirkin, B.L., Hogenkamp, H.P., et al.Effect of adenosine analogues on protein carboxylmethyltransferase, S-adenosylhomocysteine hydrolase, and ribonucleotide reductase activity in murine neuroblastoma cellsCancer Res.47(14),3656-3661(1987)
Dung, T.T.M., Yi, Y.-S., Heo, J., et al.Critical role of protein L-isoaspartyl methyltransferase in basic fibroblast growth factor-mediated neuronal cell differentiationBMB Rep.49(8),437-442(2016)
Huang, H.-M., Tam, M.F., Tam, T.-C.S., et al.Proteomic analysis of stable protein methylation in lymphoblastoid cellsJ. Biochem.132(5),813-818(2002)
Miranda, T.B., Cortez, C.C., Yoo, C.B., et al.DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylationMol. Cancer. Ther.8(6),1579-1588(2009)
