Doxifluridine
Cat. No.：YN290498
| 产品名称: | Doxifluridine |
| CAS No.: | 3094-09-5 |
| Chemical Name: | 5'-deoxy-5-fluoro-uridine |
| Synonyms: | 去氧氟尿苷; Ro 21-9738; 5-Fluoro-5'-deoxyuridine; 5'-DFUR |
| 分子量: | 246.19 |
| 分子式: | C₉H₁₁FN₂O₅ |
| SMILES: | C[C@@H]1[C@H]([C@H]([C@H](N2C(NC(C(F)=C2)=O)=O)O1)O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Doxifluridine是胸苷磷酸化酶活化剂，对PC9-DPE2细胞的IC50为0.62 μM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ozawa, S., Hamada, M., Murayama, N., et al.Cytosolic and microsomal activation of doxifluridine and tegafur to produce 5-fluorouracil in human liverCancer Chemother. Pharmacol.50(6),454-458(2002)
Kato, Y., Onishi, H., and Machida, Y.Contribution of chitosan and its derivatives to cancer chemotherapyIn Vivo19,301-310(2005)
Konishi, H., Yoshimoto, T., Morita, K., et al.Depression of phenytoin metabolic capacity by 5-fluorouracil and doxifluridine in ratsJ. Pharm. Pharmacol.55,143-149(2003)
Miwa, M., Ura, M., Nishida, M., et al.Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissueEur. J. Cancer34(8),1274-1281(1998)
