Perhexiline maleate
Cat. No.：YN482023
CAS No. ：6724-53-4
| 产品名称: | Perhexiline maleate |
| CAS No.: | 6724-53-4 |
| Chemical Name: | 2-(2,2-dicyclohexylethyl)-piperidine, 2Z-butenedioate |
| Synonyms: | 马来酸哌克昔林 |
| 分子量: | 393.56 |
| 分子式: | C₂₃H₃₉NO₄ |
| SMILES: | O=C(O)/C=C\C(O)=O.C1(CC(C2CCCCC2)C3CCCCC3)NCCCC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Perhexiline maleate是有效的肉碱棕榈酰转移酶1 (carnitine palmitoyltransferase 1) 抑制剂，对大鼠心脏和肝脏CPT 1的IC50值分别为77 和 148 μM。 |
| IC50和靶点: | |
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Kennedy, J.A., Unger, S.A., and Horowitz, J.D.Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodaroneBiochem. Pharmacol.52(2),273-280(1996)
Kennedy, J.A., Kiosoglous, A.J., Murphy, G.A., et al.Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated rat heartJ. Cardiovasc. Pharmacol.36(6),794-801(2000)
Ashrafian, H., Horowitz, J.D., and Frenneaux, M.P.PerhexilineCardiovasc. Drug Rev.25(1),76-97(2007)
Balgi, A.D., Fonseca, B.D., Donohue, E., et al.Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signalingPLoS One4(9),e7124(2009)
